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CONCLUSION: This preliminary study suggests that CES may reduce symptoms of anxiety in GAD. 9(2) 2005 The use of Cranial Electrotherapy Stimulation (CES) to treat depression and anxiety is reviewed.We hope that these preliminary results will encourage further research to explore the use of CES in clinical settings. The data submitted to the Food and Drug Administration (FDA) for approval of medication in the treatment of depression are compared with CES data. (Pub Med link) More prevalent in women than men, clinical depression affects approximately 15 million American adults in a given year.Proposed method of action, side effects, safety factors, and treatment efficacy are discussed. Psychopharmaceuticaltherapy accompanied by psychotherapy and wellness interventions (e.g., nutrition, exercise, counseling) is effective in 80% of diagnosed cases.The results suggest there is sufficient data to show that CES technology has equal or greater efficacy for the treatment of depression compared to antidepressant medications, with fewer side effects. A lesser known adjunctive therapy is that of cranial electrotherapy stimulation (CES).

RESULTS: Analysis of covariance revealed a significant difference between the active CES group and the sham CES group on anxiety (p=0.001, d=0.94) and on depression (p=0.001, d=0.78) from baseline to endpoint of study in favor of the active CES group. (Pub Med link) BACKGROUND: Cranial electrotherapy stimulation (CES) is a noninvasive procedure that has been used for decades in the United States to treat anxiety, depression, and insomnia in the general population.

The primary efficacy measures were the Hamilton Rating Scale for Anxiety (HAM-A) and the Clinical Global Impressions-Improvement (CGI-I) scale.

Response to treatment was defined as a reduction of 50% or more on the HAM-A and a CGI-I score of 1 or 2 ("much improved" or "very much improved," respectively).

Twelve studies have been conducted using the Fisher Wallace Stimulator®, including a double-blind, placebo-controlled depression study at Mount Sinai Beth Israel Hospital that was published in the Journal of Nervous and Mental Disease in 2015. Symptom non-remitters from both groups received an additional 2 weeks of open-label active treatment. (Pub Med link) Anxiety disorders are among the most prevalent mental disorders and are usually treated with medication and/or psychotherapy.

The Fisher Wallace Stimulator® is frequently used by top substance abuse clinics, such as Phoenix House where a 392-subject study conducted in 2009 found the device increased 90-day rehab retention by 50%. Greenman, BA, Siva Sundeep Koppolu, MBBS, Maria Varvara, MD, Zimri S. Active CES treatment but not sham treatment was associated with a significant decrease in the Beck Depression Inventory (BDI) scores from baseline to the second week (p = 0.003) maintaining significance until week 4 (p = 0.002). When anxiety disorders are accompanied with comorbid depression, this further complicates the treatment process.

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